We host news of discoveries in various fields of science with the focus on space, medical treatments, fringe science, microbiology, chemistry and physics, while providing commercial and cultural contexts and deeper insight. @http://koyalgroupinfomag.com/blog/

Sunday, January 18, 2015

The Koyal Group Info Mag Review - Philae Comet Lander Eludes Discovery

Efforts to find Europe's lost comet lander, Philae, have come up blank.

The most recent imaging search by the overflying Rosetta "mothership" can find no trace of the probe.

Philae touched down on 67P/Churyumov-Gerasimenko on 12 November, returning a swathe of data before going silent when its battery ran flat.

European Space Agency scientists say they are now waiting on Philae itself to reveal its position when it garners enough power to call home.

Researchers have a pretty good idea of where the robot should be, but pinpointing its exact location is tricky.

On touchdown, Philae bounced twice before coming to rest in a dark ditch.

This much is clear from the pictures it took of its surroundings. And this location, the mission team believes, is just off the top of the "head" of the duck-shaped comet.

The orbiting Rosetta satellite photographed this general location on 12, 13 and 14 December, with each image then scanned by eye for any bright pixels that might be Philae. But no positive detection has yet been made.

Rosetta has now moved further from 67P, raising its altitude from 20km to 30km, and there is no immediate plan to go back down (certainly, not to image Philae's likely location).

Even if they cannot locate it, scientists are confident the little probe will eventually make its whereabouts known.

As 67P moves closer to the Sun, lighting conditions for the robot should improve, allowing its solar cells to recharge the battery system.
The latest assessment suggests communications could be re-established in the May/June timeframe, with Philae distributing enough electricity to its instruments to resume operations around September.

This would be at perihelion - the time when the comet is closest to the Sun (185 million km away) and at its most active.

Scientists continue to pore over the data Philae managed to send back before going into hibernation.

Some of the results - together with ongoing Rosetta observations - were reported at the recent American Geophysical Union meeting in San Francisco.

Highlights include a clearer idea of the nature of the comet's surface. Researchers say this appears to be covered in many places by a soft, dusty "soil" about 15-20cm in depth.

Underneath this is a very hard layer, which is thought to be mainly sintered ice.

The conference had the rare opportunity to see pictures from Rosetta's Osiris camera system.
These high-resolution images are not normally shown publicly because the camera team has been given an exclusive period to study the data and make discoveries.

Among them was a shot looking into a pit on the surface, revealing an array of rounded features that the Osiris team has nicknamed "dinosaur eggs".

These features have a preferred scale of about 2-3m and may be evidence of the original icy blocks that came together 4.5 billion years ago to build the comet.

The dino eggs have been seen at a number of locations, including in cliff walls.

Early interpretations of the general surface of the comet indicate that many structures are probably the result of collapse over internal voids.

Although a small body just 4km across, 67P's gravity is still strong enough to shape depressions and arrange fallen boulders.

A good example of this is in "Hapi" valley - the giant gorge that forms the "neck" of the comet.

It contains a string of large blocks at its base, which one Osiris team-member argued very likely fell from the nearby vertical cliff dubbed "Hathor".

All the surface features on 67P carry names that follow an ancient Egyptian theme.


Hapi was revered as a god of the Nile. Hathor was a deity associated with the sky.

Sunday, December 28, 2014

The Koyal Group Info Mag: E-readers may Cause Poor Sleep, Health

A new research regarding healthy sleep might get you thinking twice about reading from your e-reader or tablets before dozing off at night.

According to a study from Brigham and Women's Hospital, people who read on a lit screen before sleeping tend to fall asleep later as opposed to those who read on a paperback.

The study which was printed in Proceedings of the National Academy of Sciences is the newest contribution to an increasing number of studies pointing to backlit devices, like our mobile phones and tablets, as culprits of sleep problems.

Anne-Marie Chang, a neuroscientist who headed the project said, "It seems that use of these devices in the evening before bedtime really has this negative impact on our sleep and on your circadian rhythms."

The study was conducted in a lab with 12 people who were monitored for 2 weeks. Every evening, they were asked to read for 4 hours -- the first 5 days from an iPad and the next 5 days from a paperback. Once the subjects went to bed every 10pm, they were closely monitored for physiological changes.

It turned out that when the subjects read on screens, their circadian rhythms were disrupted and melatonin production was suppressed, leading to less deep sleep and feeling of tiredness the next day.

Chang advised that the proper recommendation should be to set aside electronic devices a couple of hours before sleeping and read printed book instead. Ebook devices that do not have backlit screens will also be better. According to The Koyal Group Info Mag researchers, any device that gives off blue wavelength of light is problematic as a person will tend to hold it closer to the eyes.

Professor Charles Czeisler, one of the lead researcher said, "The light emitted by most e-readers is shining directly into the eyes of the reader, whereas from a printed book or the original Kindle, the reader is only exposed to reflected light from the pages of the book. Sleep deficiency has been shown to increase the risk of cardio diseases, metabolic diseases and cancer. Thus, the melatonin suppression that we saw in this study among participants when they were reading from the light-emitting e-reader concerns us."

Meanwhile, other scientists are cautioning the public in drawing conclusions from the said study. This is because critical changes were observed in a controlled environment like a laboratory compared to the real-life setting.

Their experiment conducted in a lab does not effectively mimic the setup in real life where people are naturally exposed to sunlight. For instance, the low light in the lab might have affected them in a way that it made them sensitive to light from screens. As The Koyal Group Info Mag said, a person exposed in mere room light the whole day could be more sensitive to the light from an ebook reader than a person who had been exposed to sunlight outside the whole day.

However, they all agree that the blue light wavelength emitted by devices like laptops, tablets and mobile phones has negative effects and should be avoided at least before bedtime.

In a related research conducted by Mariana Figueiro of Rensselaer Polytechnic Institute in 2012, they found that subjects who use an e-reader device like a tablet before going to sleep at night had lower melatonin levels after using it for 2 hours. But they clarified that the lit screen is only one of the contributing factor.

Tuesday, December 9, 2014

The Koyal Group Info Mag Review: Shaping Public Perceptions of Radiation Risk

On Monday, November 17, the US House of Representatives passed H.R. 5544, the Low Dose Radiation Research Act, which called for the National Academies to “conduct a study assessing the current status and development of a long-term strategy for low dose radiation research.”

Coincidentally that was the same day that the National Academy of Sciences hosted a publicly accessible, all day meeting to determine if there had been enough new developments in radiation health effects research to justify the formation of a new BEIR (Biological Effects of Ionizing Radiation) committee. If formed, that would be BEIR VIII, the latest in a series of committees performing a survey of available research on the health effects of atomic (now ionizing) radiation.

I had the pleasure of attending the meeting, which was held in the ornate NAS building on Constitution Avenue in Washington, DC. There were about 20 presenters talking about various aspects of the scientific and political considerations associated with the decision to form BEIR VIII. Several of the presenters had performed experimental research under the currently moribund Department of Energy’s Low Dose radiation research program.

That intriguing program was using modern genetics techniques to learn a great deal about the dynamic nature of DNA in organisms and about the ways that living tissues isolate and repair recurring damage that comes as a result of metabolic processes, heat, chemicals and ionizing radiation. It was defunded gradually beginning in 2009 and completely by 2011, with the money making its way to solar and wind energy research as the Office of Science shifted its priorities under a flat top line budget.

The agenda allocated a considerable amount of time for public comments. There were a couple of members of the audience interested in the science falsifying the “no safe dose” model who took advantage of the opportunities to speak, but so did a number of professional antinuclear activists from Maryland, Ohio, New York and Tennessee.

Need Better Results This Time

An epic struggle with important health, safety, cost and energy abundance implications is shaping up with regard to the way that the officially sanctioned science and regulatory bodies treat the risks and benefits associated with using ionizing radiation at low doses and dose rates for medical uses, industrial uses and power production.

We must make sure that this battle for science, hearts and minds is not as asymmetrical as the one fought in the period between 1954-1964. One skirmish in the battle worth winning will be to encourage the passage of the Low Dose Radiation Research Act and the annual appropriations that will enable it to function long into the future.

Here is a brief version of that lengthy prior engagement, where there were huge winners and losers. Losers included truth, general prosperity, peace and the environment. Partial winners included people engaged in the global hydrocarbon economy in finance, exploration, extraction, refinement, transportation, tools, machines and retail distribution. There were also big financial winners in pharmaceuticals, medical devices, oncology, and agriculture.

Rockefeller Funded Survey

During a 1954 Rockefeller Foundation Board of Trustees meeting, several of the trustees asked the President of the National Academy of Sciences (NAS) if his esteemed organization would be willing to review what was known about the biological effects of atomic radiation.

The board did not have to pick up the phone or send a letter to make that request. Detlev Bronk, who was the serving president of the NAS, was already at the table as a full member of the Rockefeller Foundation Board of Trustees. The board agreed that, based on their interpretations of recent media coverage, the public was confused and not properly informed about the risks of radiation exposure and the potential benefits of the Atomic Age.
The tasking given to the NAS was to form a credible committee that would study the science and issue a report “in a form accessible to seriously concerned citizens.”1

Aside: For historical context, that Foundation board meeting took place within months after President Eisenhower made his “Atoms for Peace” speech in December 1953. That speech to the United Nations announced a shift in focus of the Atomic Age from weapons development to more productive applications like electrical power generation and ship propulsion.

At the time the request to the NAS was made, the Rockefeller Foundation had been funding radiation biology-related research for at least 30 years, including the Drosophila mutation experiments that Hermann Muller conducted during the 1920s at the University of Texas. Foundation board members and supported scientists had been following developments in atomic science since the earliest discoveries of radiation and the dense energy stored inside atomic nuclei.

In March 1948, the Tripartite Conferences on radiation protection, a group that included experienced radiation researchers and practitioners from the US, Canada and the UK, had determined that the permissible doses for humans should be reduced from 1 mGy/day (in SI units) to 0.5 mGy/day or 3 mGy/week.

That reduction was not made because of any noted negative health effects, but to provide an additional safety factor.

In between these two extremes there is a level of exposure, — in the neighborhood of 0.1 r/day — which all experience to date show to be safe, but the time of observation of large numbers of people exposed at this rate under controlled conditions, is too short to permit a categorical assertion to this effect.2

End Aside.

Biological Effects of Atomic Radiation

The first NAS Biological Effects of Atomic Radiation committee began its work in April 1955. There were six subcommittees, each of which authored a section of the committee’s report. The report was identified as a preliminary version that was to be followed with a more technically detailed report scheduled to appear within the next couple of years, if desired by responsible government agencies.

Unlike the documents supporting the permissible dose limits that came out of the Tripartite Commission mentioned in the aside above, the NAS BEAR 1 committee report, especially the section from the Genetics Committee, was professionally promoted and received extensive media coverage and public attention.


The NAS held a press conference announcing the release of the report and answering questions in Washington, DC on June 12. Among other media attention, that press conference resulted in no less than six related articles in the June 13, 1956 edition of the New York Times. Several additional articles were published during the following weeks. The selection of pieces included a lengthy article that started at the top of the right hand column of the paper and continued with another 20-25 column inches on page 17. Read full article here


Sunday, December 7, 2014

The Koyal Group Info Mag Review P53: The Gene That Cracked the Cancer Code by Sue Armstrong – review

“A cure for cancer” – the phrase is so often repeated, surely it must finally materialise? To anyone not familiar with the developing story of cancer research, the position seems tragically unsatisfactory. Billions of pounds and decades of work by thousands of researchers have produced much better prognoses for some cancers, but harsh forms of chemotherapy and radiotherapy are still the standard treatment and the much sought-after magic cure remains tantalisingly out of reach.



As Sue Armstrong points out at the beginning of her book, while we may naively wonder why so many people get cancer, researchers are asking “Why so few?”. Every time a cell divides – skin and digestive-tract cells are constantly proliferating – there is a possibility of genetic errors. For cancer to develop, it requires the control mechanism in just one cell to be thrown into disorder, resulting in unlimited replication of that rogue cell. Considering the stupendous number of cell divisions occurring in the human body the development of cancer is rare. Scientists have long suspected that there is a very powerful protective mechanism at work.


P53 (the name refers to a protein of molecular weight 53 kilodaltons) is the cancer prophylactic for most multicellular organisms; it has been dubbed the guardian of the genome. While cancer has many causes and can be insidiously malignant throughout the body, p53 is the single most unifying factor in the disease: for most kinds of cancer to develop, p53’s suppressor activity has to have been disabled.

It has taken scientists a long time to establish some of the basic facts about cancer. In 1911 the pathologist Peyton Rous reported a virus that caused cancer in chickens. For decades this finding was dismissed: cancer, according to the official line, could not be caused by a virus. Rous lived long enough to see Francis Crick and James Watson’s double helix structure of 1953 establish DNA’s role at the heart of life and for his own theory to be subsequently vindicated; he received the Nobel prize in 1966 for his pioneering work.

How did we come to probe these minute molecular workings of nature? Most popular texts on genomics and molecular biology blithely report the results without offering any insight into how the scientists have reached their conclusions. Armstrong’s book has one of the best accounts I’ve read of how science is actually performed. She asks, what can they actually see? When it comes to a gene, which is only two nanometres wide, the answer is “nothing”; they work by inferring from experiments on things that they can see. As she says: “It is the ‘unseeable’ nature of molecular biology … that makes it so difficult to grasp.” She quotes one of her scientists, Peter Hall: “it’s based on faith, ultimately.” And even when scientists have a good sense of what their experiments are telling them, they’re up against the fact that life is an immensely complicated process: we can land a probe on a distant comet after a 10-year flight because the Newtonian clockwork of bodies in space is predictable. But all-embracing laws of biology are hard to find.

The process of discovery goes like this (and p53 is a classic example): something unexpected and odd turns up; investigation begins; its character gradually becomes clearer but its purpose remains a mystery; then evidence accumulates to suggest a function. That evidence is often misleading and, in the case of p53, a function diametrically opposed to the true one was ascribed to it for 10 years: it was thought to be a cancer-causing protein. Then came the moment of clarity and the potentially great unifying principle was born: in 1989, P53 was revealed as the master tumour suppressor – an order was established at last.

There are great hopes that our knowledge of p53 will lead to novel cancer treatments, but the pattern has grown much more complicated since then. In some situations p53 can cause cancer. For cancers to grow they need a mutated and disabled p53: in science, these cycles of discovery go on forever, and so will the battle between cancer and p53.

But progress is being made. One of the brightest hopes for therapy using p53 is in families with a predisposition to cancer. The reason for this blight is that the family members have each inherited a mutant copy of p53 and are therefore without the normal protection it provides. An experimental gene therapy (Advexin) already exists to correct this, but in 2008 the US regulatory body refused to license the treatment. A similar product, Gendicine, is licensed in China and approval for its clinical use is being sought in the US. One common story in today’s medical research is of remarkable possibilities constantly being blocked by a sluggish regulatory system and the skewed priorities of Big Pharma, which prefers to develop bestselling drugs that will have the widest use.


Armstrong’s book will offer many readers a sense of hope, but might also induce intense frustration at the long time it takes for discoveries in the lab to filter down to hospitals and the marketplace. Nevertheless, we can be sure that p53, even if it is not the “cure for cancer”, will have an honourable role to play in our attempts to find one.

Monday, December 1, 2014

The Koyal Group Info Mag Review: In the Digital Age, Science Publishing Needs an Upgrade (Op Ed)



Daniel Marovitz is CEO of Faculty of 1000. Faculty of 1000 is a publisher for life scientists and clinical researchers, and comprises of three services; F1000Prime, F1000Research and F1000Posters. F1000Research is an open science publishing platform for life scientists that offers immediate publication and transparent peer review. Before that, he was the CEO and co-founder of Buzzumi, a cloud-based enterprise software company. He contributed this article to Live Science's Expert Voices: Op-Ed & Insights.

Quick quiz, which is bigger: the global music industry or scientific publishing? You may be surprised to learn that the music industry racks up $15 billion each year in sales, whereas scientific publishing quietly brings in $19 billion. This "under-the-radar" colossus gets very little attention, yet influences us all.

In many ways, published science tracks and influences the course of our species on this planet. It enables scientists to find out what other researchers are working on and what discoveries they have made. It helps governments decide where to invest and helps universities decide whom to hire. Most people don't give it a second thought but they should. All of us are consumers of science, and perhaps most crucially, all of us are eventually medical patients dependent on the discoveries published in medical journals. The way science is disseminated and the way articles are published is not just a geeky question for librarians — it impacts our society in profound ways.


The history of scientific journals dates back to 1665, when French Journal des sçavan and the English Philosophical Transactions of the Royal Society first published research results. Around the same time, the first peer review process was recorded at the Royal Society of London. By the 20th century, peer review became common practice to help allocate scientific funding, and before the Internet, all scientific journals were published on paper.

Paper costs money to buy, more money to print, and even more money to transport. It made sense that journals worked hard to find the "best" studies because they were constrained to publishing 10 to 20 articles each month. They limited the number of pages authors could write and severely limited (and sometimes charged the authors extra for) color and additional images. The process was long and laborious for everyone involved, and was constrained by the limits and costs of a necessarily analog world.

You would naturally assume that the Internet Age would have changed all of that, but while all journals now publish online, most of the process is still based on a paper past. This means many perfectly sound articles are rejected, articles take too long to be published, and most articles are published with conclusions, but without the data that supports them. Enough data should be shared by authors to ensure that anyone can replicate their research efforts and achieve similar results.

Such processes seriously bias what is published, impacting all aspects of science and thus society: from new scientific discoveries and the development of new medicines, to scientists' livelihoods and how public money is spent.


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Monday, November 17, 2014

Koyal Info Mag History's first: Space probe lands on comet


Twenty years ago, a space mission to land a probe on a comet was envisioned. And now, ten years and 6 billion kms after, the Rosetta mission have seen success.

It's undoubtedly a resounding accomplishment for European Space Agency (ESA) which launched the Rosetta mission in March 2004. After blasting off from Kourou spaceport of French Guiana, Rosetta and Philae have logged at least 6 billion kms just to reach the comet.
For a time, the spacecraft had gone on standby for almost 3 years. Apparently, it had gone 500 million miles away from the sun that the solar panels can't absorb enough energy to recharge and keep things going. Fortunately, the Rosetta came out of its hibernation just this January and approached its target: comet 67P/Churyumov-Gerasimenko.

The comet, discovered in 1969, orbits the sun at the speed of 135,000 km/h. Measuring 4-km wide, the comet's shape is similar to that of a rubber duck which initially left people doubting if a landing would be possible at all. (This is because if the Philae lander touched down on uneven surface, it could turn over the wrong side -- and has no way to right itself up.)

After its separation from its carrier, Philae started its precarious  seven-hour descent onto the comet.

For the controller team, those were 7 hours of nerve-wracking anticipation, especially as a problem arose just at a critical moment. There seemed to be an issue with its thruster which could result in a rough landing at best. Their failure to amend the fault almost resulted in the cancellation of the mission. Eventually, they decided to proceed in spite of it.

Inside the control center of ESA  in Darmstadt, Germany, tensions were high.

Finally, around 4pm (GMT), Philae's communications reached Earth: touchdown.

“We are there. We are sitting on the surface. Philae is talking to us. We are on the comet,” said Stephan Ulamec, Philae's lander manager at the control room.

The space mission has already registered a number of firsts;  including the first spacecraft to come into close orbit around a comet and of course the first to land a probe. And if things go well, it could also be the first spacecraft to travel with a comet as it circles the sun.

ESA's director general, Jean-Jacques Dordain announced, "We are the first to do this, and that will stay forever."

During another  interview with Koyal Info Mag, Dordain noted, "This is a big step for human civilization."

After putting the Philae lander on ground, the Rosetta spacecraft is expected to orbit around the comet and take more images as well as collect various data as it travels toward the sun.

The Rosetta mission will be completed in December 2015, though if there's enough fuel in the spacecraft it might be given a 6-month extension to do even more daring projects. Philae itself has enough juice to continue working until March before its electronics get fried by the sun's heat. However, it might still continue to cling to the comet for around 6 years before losing its grip.

This daring space mission aims to further study the molecular and physical composition of a comet, believed to be made from materials that existed even before the solar system's creation. Koyal Info Mag hopes more will be known of how the solar system formed and how comets are instrumental to the life-sustaining qualities of a planet like Earth.

Sunday, November 16, 2014

The Koyal Group Info Mag: How turning science into a game rouses more public interest


Chris Lintott first met Kevin Schawinski in the summer of 2007 at the astrophysics department of the University of Oxford. Lintott had just finished a PhD at the University College of London on star formation in galaxies. He was also something of a minor celebrity in the astronomy community: he was one of the presenters of the BBC's astronomy programme The Sky at Night alongside Sir Patrick Moore, and had written a popular science book called Bang!: The Complete History of the Universe with Moore and Brian May, the Queen guitarist and astrophysicist. "I went to give a seminar talk as part of a job interview," Lintott recalls. "And this guy in a suit jumped up and started having a go at me because I hadn't checked my galaxy data properly. I thought it was some lecturer who I'd pissed off, but it turned out to be Kevin [Schawinski], who was a student at the time."

Most galaxies come in two shapes: elliptical or spiral. Elliptical galaxies can have a range of shapes, from perfectly spherical to a flattened rugby-ball shape. Spirals, like the Milky Way, have a central bulge of stars surrounded by a thin disk of stars shaped in a spiral pattern known as "arms". The shape of a galaxy is an imprint of its history and how it has interacted with other galaxies over billions of years of evolution. It is a mystery to astronomers why they have these shapes and how the two geometries related to one another. For a long time, astronomers assumed that spirals were young galaxies, with an abundance of stellar nurseries, where new stars were being formed. These regions typically emitted hot, blue radiation. Elliptical galaxies, on the other hand, were thought to be predominantly old, replete of dying stars, which are colder, and therefore have a red colour. Schawinski was working on a theory which contradicted this paradigm. To prove it, he needed to find elliptical galaxies with blue regions, where starformation was taking place.

At the time, astronomers relied on computer algorithms to filter datasets of images of galaxies. The biggest bank of such images came from the Sloan Digital Sky Survey, which contained more than two million astronomical objects, nearly a million of which were galaxies, and had been taken by an automated robotic telescope in New Mexico with a two-metre mirror. The problem was that computers can easily filter galaxies based on their colour, however it was impossible for an algorithm to pick up galaxies based on their shape. "It's really hard to teach a computer a pattern-recognition task like this," says Schawinski, currently a professor in astronomy at the Swiss Federal Institute of Technology in Zurich. "It took computer scientists a decade to [teach a computer] to tell human faces apart, something every child can do the moment they open their eyes." The only way to prove this theory, Schawinski decided, was to look at each galaxy image, one by one.

Schawinski did it for a week, working 12 hours every day. He would go to his office in the morning, click through images of galaxies while listening to music, break for lunch, and continue until late in the evening. "When I attended Chris's seminar, I had just spent a week looking through fifty thousand galaxies," says Schawinski.

When Lintott moved to Oxford, he and Schawinski started debating the problem of how to classify datasets with millions of images. They weren't the only ones. "Kate Land, one of my colleagues, was intrigued about a recent paper which claimed most galaxies were rotating around a common axis," Lintott says. "Which is indeed puzzling because the expectation was that these axes would be totally random." Land needed more data, which required looking at the rotation of tens of thousands of galaxies. "Out of the blue she asked me if I thought that, if they put a laptop with galaxy images in the middle of a pub, would people classify them?" Lintott recalls.

At the time, Nasa had launched a project called Stardust@home, which had recruited about 20,000 online volunteers to identify tracks made by interstellar dust in samples from a comet. "We thought that if people are going to look at dust tracks, then surely they'll look at galaxies," says Lintott. Once it was decided they would go ahead with the project, they built a website within days. The homepage displayed the image of a galaxy from the dataset. For each image, the volunteers were asked if the galaxy was a spiral or elliptical. If a spiral, they were asked if they could discern the direction of its arms and the direction of its rotation. There were also options for stars, unknown objects and overlapping galaxies.

Charlie Surbey and Liam Sharp
The site, called Galaxy Zoo, launched on July 11, 2007. "We thought we would get at least some amateur astronomers," Lintott says. "I was planning to go to the British Astronomical Society, give a talk and get at least 50 of their members to classify some galaxies for us." Within 24 hours of its launch, Galaxy Zoo was receiving 60,000 classifications per hour. "The cable we were using melted and we were offline for a while," Schawinski says. "The project nearly died there." After ten days, users from all over the world had submitted eight million classifications. By November, every galaxy had been seen by an average of 40 people. Galaxy Zoo users weren't just classifying galactic shapes, they were making unexpected discoveries. Barely a month after launch, Dutch schoolteacher Hanny van Arkel discovered a strange green cluster that turned out to be a never-before-seen astronomical object. Christened Hanny's Voorwerp ("voorwerp" means "object" in Dutch), it remains the subject of intense scientific scrutiny. Later that year, a team of volunteers compiled evidence for a new type of galaxy -- blue and compact -- which they named Pea galaxies.

"When we did a survey of our volunteers we found out they weren't astronomers," Lintott says. "They weren't even huge science fans and weren't that interested in making new discoveries. The majority said they just wanted to make a contribution." With Galaxy Zoo, Schawinski and Lintott developed a powerful pattern-recognition machine, composed entirely of people who could not only process data incredibly quickly and accurately -- aggregating the results via a democratic statistical process -- but also enable individual serendipitous discoveries, a fundamental component of scientific enquiry. With robotic telescopes spewing terabytes of images every year, they found an answer to big data in a big crowd of volunteers. Since Galaxy Zoo's first discoveries, this pioneering approach of crowdsourcing science has gained a strong following not only with the general public but also within the scientific community. Today, there are hundreds of crowdsourcing projects involving a variety of scientific goals, from identifying cancer cells in biological tissues to building nanoscale machines using DNA. These endeavours have resulted in breakthroughs, such as Schawinski and Lintott's discoveries on the subject of star formation, that have merited publication in the most reputed scientific journals. The biggest breakthrough, however, is not the scientific discoveries per se, but the method itself. Crowdsourcing science is a reinvention of the scientific method, a powerful new way of making discoveries and solving problems that could have otherwise remain undiscovered and unsolved.

At around the time Lintott and his team were developing Galaxy Zoo, two computer scientists at the University of Washington in Seattle, Seth Cooper and Adrien Treuille, were trying to use online crowds to solve a problem in biochemistry called protein folding.

A protein is a chain of smaller molecules called amino acids. Its three-dimensional shape determines how it interacts with other proteins and, consequently, its function in the cell. Proteins only have one possible structure, and finding that structure is a notoriously difficult problem: for a given chain of amino acids, there are millions of ways in which it can be folded into a three-dimensional shape. Biochemists know thousands of sequences of amino acids but struggle to find how they fold into the three-dimensional structures that are found in nature.

Cooper and Treuille's lab had previously developed an algorithm which attempted to predict these structures. The algorithm, named Rosetta, required a lot of computer power, so it was adapted to run as a screensaver that online volunteers could install. The screensaver, called Rosetta@home, required no input from volunteers, so Cooper and Treuille had been brought in to turn it into a game. "With the screensaver, users could see the protein and how the computer was trying to fold it, but they couldn't interact with it," Cooper says. "We wanted to combine that computer power with human problem-solving."

Cooper and Treuille were the only computer scientists in their lab. They also had no idea about protein folding. "In some sense, we were forced to look at this very esoteric and abstract problem through the eyes of a child," Cooper says. "Biochemists often tell you that a protein looks right or wrong. It seemed that with enough training you can gain an intuition about how a protein folds. There are certain configurations that a computer never samples, but a person can just look at it and say, 'that's it'. That was the seed of the idea."

The game, called Foldit, was released in May 2008. Players start with a partially-folded protein structure, which has been arrived at by the Rosetta algorithm, and have to manipulate its structure by clicking, pulling and dragging amino acids until they've arrived at its most stable shape. The algorithm calculates how stable the structure is; the more stable, the higher the score.

"When we first trialled the game with the biochemists, they weren't particularly excited," Cooper says. "But then we added a leaderboard, where you could see each other's names and respective scores. After that, we had to shut down the game for a while because it was bringing all science to a halt."


Foldit turned the goal of solving one of biochemistry's hardest problems into a game that can be won by scoring points. Over the past five years, over 350,000 people have played Foldit; these players have been able to consistently fold proteins better than the best algorithms. "Most of these players didn't have a background in biochemistry and they were beating some of the biochemists who were playing the game," Cooper says. "They also discovered an algorithm similar to one that the scientists had been developing. It was more efficient that any previously published algorithms."